Antigen Processing Mechanisms in Antigen Presenting Cells.
نویسندگان
چکیده
منابع مشابه
Comparing Proteolytic Fingerprints of Antigen-Presenting Cells during Allergen Processing
Endolysosomal processing has a critical influence on immunogenicity as well as immune polarization of protein antigens. In industrialized countries, allergies affect around 25% of the population. For the rational design of protein-based allergy therapeutics for immunotherapy, a good knowledge of T cell-reactive regions on allergens is required. Thus, we sought to analyze endolysosomal degradati...
متن کاملAntigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this face...
متن کاملEndocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells.
Although dendritic cells are the most potent of all antigen presenting cells, they have paradoxically been regarded as having only a minimal capacity for endocytosis, which is a crucial step in antigen processing prior to presentation. Previous studies of dendritic cells, which are only available in small numbers, have been restricted to measurement of long-term endocytosis and so have stressed...
متن کاملDendritic cells as specialized antigen-presenting cells.
Renewing interest in cancer immunotherapy reflects the excellent results that have been obtained in animal models and the promising results in early clinical trails with dendritic cell (DC) based approaches. The central role that DCs play in the initiation of an immune response raises the possibility of using them to trigger specific anti-tumor immunity. In addition, deeper knowledge of DC biol...
متن کاملAntigen-Presenting Cells: Professionals and amateurs
Professional antigen-presenting cells, notably dendritic cells, play a key role in stimulating naive T cells--but nonprofessional antigen-presenting cells, such as fibroblasts, may also contribute to this process.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kagaku To Seibutsu
سال: 1992
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu1962.30.81